2017 Bristol-Myers Squibb - UCLA Lectureship

Discovery of Pyridine Amide Based Inhibitors of Interleukin Receptor- Associated Kinase 4 (IRAK4) for the Treatment of Lupus

Speaker: Dr. John Hynes,
Senior Principal Scientist, Immunology Discovery Chemistry, Bristol-Myers Squibb Co.

IRAK4 is a member of the IRAK family of serine-threonine kinases which signals downstream of toll-like receptors (TLRs) and IL-1 receptors. TLRs are centrally critical to innate immune system defense due to their ability to recognize molecular patterns associated with various pathogens. These receptors also detect damage-associated molecular pathogens (DAMPs) generated in the course of chronic autoimmune disease states such as lupus. The location of IRAK4 downstream of these innate immune system signaling receptors has resulted in significant interest in therapeutic targeting of IRAK4 in autoimmune diseases.

When: May 18, 2017, 1:30 pm
Where: Cram Conference Room - 3440 Molecular Sciences Bldg., UCLA


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